Abstract
The phosphate potential of adenine nucleotides and the redox state of nicotinamide-adenine dinucleotides in equilibrium with them in the various compartments of hepatocytes perform the role of the principal integrative factors in the regulation of metabolism [i]. Administration of nicotinamide, accompanied by an increase in the NAD+/NADH and ATP/ADP.P i ratios of the cytosol [i, 6], can be used to assess the role of these "coenzyme loops" [5] in the regulation of individual processes of carbohydrate and lipid metabolism in various physiological and pathological states. The study of systems of adenine and nicotinamide nucleotide systems on models with different hormonal backgrounds is particularly interesting, because the character and mechanisms of interaction of hormones and factors of nonhormonal nature in the regulation of metabolic processes have been inadequately studied.
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