Abstract
In primary chick embryo cells aged <i>in vitro, </i>vaccinia virus replication is drastically inhibited by pretreatment with low doses of interferon. The antiviral state was established with doses about ten times smaller than those required with normal primary chick cells. Viral protein synthesis is also highly sensitive to chick interferon in these cells. Cell-free lysates from aged chick cells translated several viral and globin mRNAs efficiently. While drastic inhibition of vaccinia virus-specific protein synthesis by interferon treatment could be detected in the intact aged cells, the translation in the cell-free lysate was not significantly affected by pretreatment of the cells with interferon or interferon followed by infection with vaccinia WR.
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