Abstract
Chromatin properties which reflect availability of DNA phosphates unattached to proteins and DNP conformation were studied in onion root tip cells subjected to hycanthone treatment. The hycanthone action at various drug concentrations was monitored by detecting chromosome aberrations and changes in mitotic index frequencies.The spectral shifts and changes in anisotropy patterns found in hycanthone-treated cells stained with a toluidine blue solution at pH 4.0 indicate decreased availability on free DNA phosphates and some uncoiling of the DNA helix promoted by the drug. The data are suggestive of attachment of at least one of the nitrogen groups of intercalated hycanthone molecules to DNA phosphates.
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