Abstract
The permeability to potassium and water of the isolated gastric mucosa of the frog, Rana pipiens, has been studied. Measurements were realized in spontaneously secreting and histamine (2·10 −5 M) stimulated mucosae in vitro. Electrical potential differences and net potassium fluxes were measured in solutions containing known potassium concentrations. Permeability coefficients for potassium of 11.8·10 −6 and 22.6·10 −6 cm/sec were calculated for the spontaneously secreting and histamine-stimulated mucosae, respectively. A diffusion permeability coefficient for water of 0.42·10 −4 ml/cm 2·sec, was obtained for the spontaneously secreting mucosa using 3H-labelled water; addition of histamine did not change the water diffusion rate. Values of 2.2·10 −2 and 3.7·10 −2 cm 4/sec per mole of glucose were obtained for the permeability coefficient for water filtration in the spontaneously secreting and histamine-stimulated mucosae, respectively. From these findings, it may be concluded (a) that stimulation with histamine increases the permeability of the mucosa to potassium and to water filtration, and (b) that the main barrier for the diffusion of water and that for filtration of water are different, the one for diffusion being insensitive to histamine at the concentration used.
Published Version
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