Abstract
The action of gentamicin on penicillin G-induced spheroplasts was studied in 4 Proteus strains (1 <i>Proteus mirabilis</i>, 2 <i>P. rettgeri</i>, 1 <i>P. vulgaris</i>). Although marked synergism could be demonstrated, this synergism between penicillin G and gentamicin was not increased by spheroplast formation. No greater bactericidal activity of gentamicin resulted when Proteus rods were transformed into spheroplasts by penicillin. Gentamicin disc sensitivity of Proteus spheroplasts after inactivation of penicillin was not better than of Proteus rods. Gentamicin and probably other aminoglycosides should not be recommended as drugs of choice for treatment of spheroplast or L-form infections.
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