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Abstract
The action of estrone, 17β-estradiol, and estriol on the degree of binding of histones with DNA in reconstituted nucleohistones and the effect of these hormones on thermal denaturation of nucleoproteins were studied. Estrogens in concentrations of 10−5 M were shown not to change the protein/DNA ratio by weight in partially reconstituted F1, F2a, F2b, and F3 nucleohistones and in total nucleohistone reconstituted from DNA and an equimolar complex of histones F2a, F2b, and F3. Treatment with estrogens in the above-mentioned concentration does not change the melting point of any of the nucleohistones studied. The effect of estrogens on thermal denaturation of total nucleohistone and of partially reconstituted nucleohistones F2a, F2b, and F3 consists of an increase in the hyperchromic effect of the first phase of melting and a corresponding decrease in the hyperchromic effect of the other phases. Estrogens did not change the thermal denaturation profile of partially reconstituted nucleohistone F1.
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