Abstract
The aim of this study was to investigate the effects of Baccharis coridifolia essential oil on the Activity of Antibiotics. Assays were performed with ampicillin (10 μg), cephalothin (30 μg), chloramphenicol (30 μg), gentamicin (10 μg) and tetracycline (30 μg) alone and in combination with the essential oil (4% v/v) through the disk diffusion susceptibility test. The results showed the effects of essential oil on the activity of the antibiotics tested. Zones of inhibition of bacterial growth with different diameters were observed surrounding the antibiotic disks, whether or not they were impregnated with the essential oil. The occurrence of the synergistic or antagonistic effect was observed in both bacterial strains assessed—Staphylococcus aureus (ATCC-25923) and Escherichia coli (ATCC-25922). These results show that the use of products derived from plants can, in some cases, interfere with the effectiveness of antibiotics during clinical therapy.
Highlights
The use of natural products as a therapeutic resource is as old as human civilization
The results showed the effects of essential oil on the activity of the antibiotics tested
The occurrence of the synergistic or antagonistic effect was observed in both bacterial strains assessed—Staphylococcus aureus (ATCC-25923) and Escherichia coli (ATCC-25922)
Summary
The use of natural products as a therapeutic resource is as old as human civilization. Plants with therapeutic properties used in traditional health care are an important source of new biologically active compounds. Plants are used concomitantly with conventional medicaments [7] In this combined use, medicinal plants and/or their byproducts may act by inhibiting or enhancing the therapeutic effect of conventional drugs, as well as not interacting in the expected way [8]. Medicinal plants and/or their byproducts may act by inhibiting or enhancing the therapeutic effect of conventional drugs, as well as not interacting in the expected way [8] In dermatology, such associative use often puts the patient at risk, as it can trigger phytodermatitis due to irritation or photosensitivity mechanisms. This practice may hinder the clinical diagnosis, as often the patients are not aware of the importance of informing health care professionals about the use of medicinal plants during a medical appointment
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