Action of cottonplant glycoproteins on the proliferative activity of cells

Abstract

A mitogenic action of the total (LLPs) and lactose-specific (LLPs-1) lectin-like proteins on the proliferation of lymphocytes and of myeloma cells in culture has been found. A dose-dependent influence of the LLPs and extensin-like proteins (ELPs) on the inclusion of3H proteins in the myeloma cells, including an antimitotic effect of the ELPs with an increase in the protein dose, has been shown; the ELPs exert an analogous action on K–562 tumor cells of human erythroblasts. The nature of the biological action of the LLPs and ELPs is discussed in connection with features of the structure of the carbohydrate fragments of the composition of the glycoproteins.