Abstract
SummaryThe action of ellagic acid, serum and acetylsalicylic acid on the frequency of thrombosis has been studied in a modification of the thrombosis model of Blake et al. (1959). Thrombi were formed in the external jugular veins of the rats by irritation with a formalin-methanol solution. The rate of thrombosis is highest with ellagic acid and lowest with acetylsalicylic acid. None of the groups of treated rats differed significantly from the control group. A short activation of coagulation with either ellagic acid or serum does not greatly enhance the thrombosis rate. The action of acetylsalicylic acid in the prophylaxis of thrombosis is not very convincing. Species differences may play a role.Exhaustive coagulation studies before and after operation showed in each group a specific behaviour of the coagulation factors. There were significant differences between thrombosis positive and thrombosis negative animals. With ellagic acid, however, there was no difference between animals with and without thrombosis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
