Abstract
The action of cholecystokinin (CCK) and caerulein upon the rabbit sphincter of Oddi was investigated by electromyography, manometry and measuring of the flow. Intravenous injection of CCK resulted in a marked rise of the sphincter activity with a maximum at the 1st min and return to the basal level at the 10th min. Injection of increasing doses of hormone showed that the effect was proportional to the logarithm of the dose. The same results were obtained with caerulein. Parallely, CCK provoked a rise of the biliary pressure also proportional to the logarithm of the dose and a reduction to the biliary flow. The discrepancies between these results and some other experiments are discussed. It is concluded that, in the rabbit, CCK increases the activity of the sphincter of Oddi.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
