Abstract
In experiments in vitro on rat epididymal adipose tissue the dose-response curves of the lipid mobilizing effects of catecholamine and oxedrine derivatives N-substituted by H-, Me-, Et-, nPr-, nBu- iPtr-, tBu- and F tBu- (phenyl- t-butyl) were investigated. In the catecholamine derivatives, the affinities were almost equal showing only a slightly rising trend towards derivatives substituted with richly branched radicals; with oxedrines, the pD 2-values rose with progressive N-substitution approximately twice as rapidly as with catecholamines. The sequence of affinities iPr > H > Me, unusual in adrenergic reactions, was observed in both homologous series.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
