Abstract
The anti-estradiol-17β activity of CN-55,945-27 (1-(2-{p-[α-(p-methoxyphenyl)-β-nitrostyryl]phenoxy}-ethyl) pyrrolidine monocitrate) can be evaluated in a 3,4 or 7 day bioassay using immature ovariectomized rats. CN-55, 945-27 inhibits the uterine weight increase induced by 0.6 μg/kg of estradiol-17β in ovariectomized, hypophysectomized and ovariectomized-hypophysectomized rats. A similar activity is also observed in hypophysectomized animals receiving either whole pituitary homogenate or luteinizing hormone. On the other hand, CN-55, 945-27 is inactive in intact animals unless a minimum dose of 1.2 μg/kg of estradiol-17β is used. The lack of activity in intact animals does not appear to be solely dependent upon the uterine response to estradiol-17β. Estradiol-17β and/or CN-55, 945-27 induced uterine weight increase differs in intact and in operated animals.
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