Abstract
The in vitro effect of aflatoxin B 1 (AFB 1) on the coupling membrane-bound and matrix NAD +-dependent dehydrogenases and electron transport complexes of guinea fowl ( Numida meleagris Pearl) liver mitochondria was investigated. Redox-dye measure ments indicated that AFB 1 (0.05 – 5 μ m) decreased the activities of the membrane-bound dehydrogenases, whereas the matrix enzymes were only inhibited at the highest toxin concentration tested. Spectrophotometric studies of the electron transfer complexes spanning the entire respiratory chain suggest that AFB 1 interferes with mitochondrial electron transport by inhibiting succinate dehydrogenase activity and the cytochrome systems.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
