Abstract
The action of 7-oxa-13-prostynoïc acid on spontaneous contractions and on PGF 2α and angiotensin II elicited contractions has been studied on rat uteri excised during pro and metaoestrus At the concentration of 5 × 10 −6M, the compound does not alter the spontaneous contractions of proestrus uteri and suppresses the phasic component of PGF 2α-elicited contractions. At the concentration of 5 × 10 −5M, 7-oxa-13-prostynoïc acid inhibits spontaneous contractions and inhibits PGF 2α-elicited contractions. In metaoestrus uteri, the inhibitory effect is not competitive. 7-oxa-13-prostynoïc acid is also able to inhibit non competitively the contractor effect of angiotensin II in proestrus uteri. This result, together with those of previous investigations performed using other prostaglandin inhibitors, suggest that the contractor effect of angiotensin II on the uterus is partially mediated by endogenous prostaglandins.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.