Abstract
Tumors were induced in CBA mice or (C57BL×CBA)F1 hybrids by application of benzo-(a) pyrene (BP), 6-methyl-BP, 6-formyl-BP, or 7,12-dimethylbenz (a) anthracene (DMBA) to the dorsal skin. If 7,8-benzoflavone (BF) was mixed with the above compounds it reduced the carcinogenic action of the methyl-substituted hydrocarbons (DMBA and 6-methyl-BP) but did not affect the carcinogenic action of BP itself or of 6-formyl-BP. The inhibitory action of BF on carcinogenesis induced by methyl-substituted hydrocarbons is due, it can tentatively be suggested, to inhibition of oxidation of the methyl group.
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