Abstract
A peptide of the pituitary pars-intermedia @-cell tropin) from genetically obese mice (ob/ob) stimulates insulin secretion in vitro [ 1,2]. P-Cell tropin (BCT) crossreacts with a COOH terminal ACTH antiserum. Experiments have now been carried out in which purified samples of BCT prepared by Bio-Gel chromatography [2] have been tested for in vivo stimulation of insulin release and of lipid synthesis in rats. The influence of BCT on lipid synthesis in adipocytes has also been investigated. The results show a significant rise in plasma insulin levels 2 mm following the injection of BCT into the jugular vein of rats. A significant increase in total lipid synthesis in the subcutaneous tissue of rats treated with BCT was demonstrated, 45 min following an injection of 3Hz0, as measured by ‘H incorporation into saponified fatty acids. BCT was also shown to stimulate total lipid synthesis in vitro in adipocytes incubated for 1 h.
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