Abstract
The work was carried out on 40 nonlinear male rats weighing 180-220 g. In the experimental group, the rats were kept on a high-calorie diet for 2 months; in the control group, only the model was reproduced without the action of EMR/UHF; in the intact group, the animals were not exposed to any influences. The course of EMR/UHF (10 procedures) was carried out daily for 2 minutes on the lumbar region in the adrenal gland projection area using the Aquaton-2 device (power flux density less than 1 μW / cm2, frequency about 1000 MHz). The objects of the study were the liver and blood. Biochemical methods were used (RNA, DNA, total protein content, liver antioxidant activity, insulin and glucose levels in the blood), transmission electron microscopy, morphometric analysis of mitochondria (number, average and total area). The use of low-intensity EMR/UHF at the background of the MS development caused an increase in a number of adaptive changes: the level of insulin in the blood increased; the content of total protein in the liver increased, and the severity of fatty degeneration decreased. The ultrastructural reorganization of hepatocytes was manifested in the activation of the protein synthesis apparatus (the phenomenon of hyperplasia of the granular endoplasmic reticulum, as well as ribosomes and polysomes). At the same time, the total area of mitochondria decreased, although their bioenergetic potential increased due to the condensation of the matrix. The revealed adaptive shifts were due to the antioxidant and membrane-stabilizing effects of EMR/UHF on general neuroendocrine and local mechanisms. Low-intensity EMR/UHF microwave can be a promising factor in the development of new methods of treatment and prevention of MS. In order to optimize the adaptive-protective and compensatory processes, as well as taking into account the decrease in the number of mitochondria, it is advisable to use EMR/UHF in more adequate modes.
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