Abstract
Event Abstract Back to Event Action control related local field potentials in the human pedunculopontine nuclei: a single case report Marcus Heldmann1*, Tino Zaehle2, Imke Galazky3, Thomas Münte1, Jürgen Voges4, Hans-Jochen Heinze3 and Hermann Hinrichs3 1 Dep. Neurology, University Medical Center SH, Germany 2 German Centre for Neurodegenerative Diseases (DZNE) Magdeburg, Germany 3 University Department of Neurology, Magdeburg, Germany 4 Department of Stereotactic Neurosurgery, Germany The pedunculopontine nucleus (PPN) is a rostral midbrain structure and an essential part of the reticular activation system and the mesencephalic locomotor region. Anatomically, the PPN is characterized by its reciprocal cholinergic and non-cholinergic connections to the basal ganglia, the thalamus and the spinal cord. It is known from the animal literature that the PPN is not only involved in sleep behavior and the control of movement, but also supports cognitive functions like attention, reward processing and learning. The PPN has recently been identified as a target for deep brain stimulation (DBS) to treat Parkinson Disease and related movement disorders such as progressive supranuclear palsy (PSP) in particular for freezing of gait and postural instability. Thus, the impact of DBS in the PPN on executive functions and the control of motor behavior in humans can be investigated. First behavioral studies reported faster reaction times and improved executive functions under active DBS, indicating an involvement of the PPN in these functions in humans. In the present single case report we recorded local field potentials from the PPN in a 71 years old PSP patient, while he performed two simple motor (tapping/task-switching) paradigms. Results clearly demonstrate an association of intracranially recoded local field potentials in the (left) PPN and the given feedback information that indicated to switch or not to switch the task set. We will discuss this finding as first direct evidence for an involvement of the human PPN in action monitoring mechanisms. Keywords: Intra-cranial Electrophysiology, PPN Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Abstracts Citation: Heldmann M, Zaehle T, Galazky I, Münte T, Voges J, Heinze H and Hinrichs H (2011). Action control related local field potentials in the human pedunculopontine nuclei: a single case report. Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00072 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Nov 2011; Published Online: 25 Nov 2011. * Correspondence: Dr. Marcus Heldmann, Dep. Neurology, University Medical Center SH, Lübeck, Germany, marcus.heldmann@neuro.uni-luebeck.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marcus Heldmann Tino Zaehle Imke Galazky Thomas Münte Jürgen Voges Hans-Jochen Heinze Hermann Hinrichs Google Marcus Heldmann Tino Zaehle Imke Galazky Thomas Münte Jürgen Voges Hans-Jochen Heinze Hermann Hinrichs Google Scholar Marcus Heldmann Tino Zaehle Imke Galazky Thomas Münte Jürgen Voges Hans-Jochen Heinze Hermann Hinrichs PubMed Marcus Heldmann Tino Zaehle Imke Galazky Thomas Münte Jürgen Voges Hans-Jochen Heinze Hermann Hinrichs Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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