Abstract
When embryos of Paracentrotus lividus are actinomycin D treated immediately after fertilization, the vegetal-animal mitotic gradient is completely disrupted. On the other hand, if the treatment is started at or after the 16-cell stage (i.e., after the segregation of the micromeres), the mitotic gradient is not affected. The hypothesis is advanced that actinomycin D inhibits a transcriptional event in the micromeres which regulates the synchronization of the cell divisions in the early cleavage stages.
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