Abstract
Actinomycin D inhibits dark repair of UV-damage in Bacillus subtilis . This inhibition is not due to an inhibition of mRNA or induced enzyme synthesis. Actinomycin D prevents the removal of UV photoproducts from DNA. After a lag, breakdown of DNA occurs in UV irradiated cells in the presence of actinomycin. It appears likely that there is no direct relationship between the dark repair process and the massive breakdown of DNA to acid-soluble fragments.
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