Abstract
Introduction: Insulin secretion is required for regulation of glucose homeostasis and its impairment leads to diabetes. Insulin is produced by the pancreatic b-cells, it is stored within insulin secretory granules (SGs) and released upon glucose stimulation. Newly synthesized insulin is preferentially released and mobile insulin SGs are more prone to undergo exocytosis. This suggests that SG age and mobility are key factors affecting insulin secretion.
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