Abstract
Mengjun Liang, Xing Zhang and Zongpei Jiang* Author Affiliations Department of Nephrology, China Received: November 27, 2019 | Published: December 04, 2019 Corresponding author: Zongpei Jiang, Department of Nephrology, The Six Affiliated Hospital, China DOI: 10.26717/BJSTR.2019.23.003919
Highlights
The mechanism of proteinuria is a hotspot for kidney disease research
Results & Conclusion: Current studies have indicated that cytoskeleton stabilization of kidney podocyte plays an important role in development of proteinuria
Calcineurin, silent normally, will be activated by increment in cytosolic Ca2+ concentration which is mainly related to mutation of transient receptor potential channel-6 (TRPC6) locating in cytomembrane of podocyte
Summary
The mechanism of proteinuria is a hotspot for kidney disease research. Proteinuria is an important sign of glomerulonephritis and is an independent risk factor for kidney disease progression. Results & Conclusion: Current studies have indicated that cytoskeleton stabilization of kidney podocyte plays an important role in development of proteinuria. Synaptopodin is a key stabilizer of actin cytoskeleton in podocyte through forming Synaptopodin-p-β-14-3-3 protein complex.
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