Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study.

Abstract

Short self-reported sleep duration is associated with dietary intake and this association may partly mediate the link between short sleep and metabolic abnormalities. Subjective sleep measures, however, may be inaccurate and biased. The objective of this study was to evaluate the associations between actigraphic measures of sleep fragmentation, efficiency and duration and energy and macronutrient intakes. We used data from a subgroup of 439 participants of the population-based cohort, Rotterdam Study. Sleep was assessed using 7-day actigraphy and sleep diaries, and dietary data with a validated food frequency questionnaire. We assessed the associations of actigraphic sleep parameters with dietary intake using multivariable linear regression models. Higher sleep fragmentation was associated with 4.19g lower carbohydrate intake per standard deviation of fragmentation {β [95% confidence interval (CI)=-4.19 (-8.0, -0.3)]; P=0.03}. Each additional percentage increase in sleep efficiency was associated with 11.1kcal lower energy intake [β (95% CI)=-11.1 (-20.6, -1.7); P=0.02]. Furthermore, very short sleep duration (<5.5h) was associated with 218.1kcal higher energy intake [β (95% CI=218.06 (33.3, 402.8), P=0.02], relative to the reference group (≥6.5 to <7.5h). We observed associations between higher sleep fragmentation with lower carbohydrate intake, and both lower sleep efficiency and very short sleep duration (<5h) with higher energy intake. The association between sleep and higher energy intake could mediate, in part, the link between short sleep or sleep fragmentation index and metabolic abnormalities.