Abstract
(1) N-terminal fragments of ACTH antagonize morphine binding to opiate specific binding sites in vitro. (2) Morphine-induced analgesia in rats can be counteracted by administration (s.c.) of ACTH analogs. (3) ACTH-like peptides produce excessive grooming in rats when intraventricularly administered. (4) Excessive grooming can also be achieved by intraventricular administration of low doses of morphine or β-LPH 61–91. (5) Peptide- or morphine-induced excessive grooming can be blocked by administration (s.c.) of specific opiate antagonists (naloxone, naltrexone). (6) The structure activity requirements for ACTH-like peptides to (a) inhibit morphine binding to opiate receptors in vitro (b) produce excessive grooming behavior and (c) counteract morphine-induced analgesia, run fairly well parallel. (7) It is concluded that a common denominator exists in the action of ACTH-like peptides and opiates on the central nervous system.
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