Abstract
Intracytoplasmic sperm injection (ICSI) allows the direct injection of a spermatozoon into an oocyte and has evolved as an assisted reproduction technique to overcome certain types of male factor infertility (1). ICSI bypasses many sperm-oocyte interactions that take place during in vivo and in vitro fertilization, thus introducing into the oocyte sperm-specific structures normally removed before the male DNA enters the ooplasm. Prominent among these is the acrosome, a secretory vesicle that covers most of the mammalian sperm nucleus (2). Exocytosis of acrosomal components is thought to aid the sperm in gaining access to the oocyte plasma membrane.
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