Abstract

ABSTRACT Objective: The concomitant presence of three histopathologically different lesions in the pituitary gland is a rare occurrence. We present a case of a woman with a large pituitary mass composed of a growth hormone–producing microadenoma, lymphocytic hypophysitis, and a Rathke cleft cyst. Methods: The clinical presentation, laboratory data, imaging studies, and pathology report of the patient's hospital course are described. Results: A 35-year-old woman presented with complaints of fever, persistent headaches, and amenorrhea for 1 year. The patient noted snoring, increase in shoe size, and bilateral hand edema for 3 months. Evaluation revealed a suprasellar mass measuring 2.1 × 1.7 × 2.7 cm with an upward mass effect on the optic chiasm. The physical exam revealed frontal bossing, wide-spaced teeth, prognathism, and sausage digits. Hormonal evaluation was consistent with acromegaly. She underwent a transsphenoidal resection of the lesion, and pathology revealed a growth hormone–producing microaden...

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