Abstract
The typical feature of acromegalic patients are large hands, feet, ears and wide noses. We have performed various anthropological measurements at yearly intervals in 23 children with UTS (aged 7 to 15.5 years). The patients received therapy with hGH (±18 - 24 U/m2/week) and Oxandrolone (0.1 mg/kg/day). Thus, we were able to investigate whether high doses of hGH may artificially cause changes of body proportions. During therapy, body height increased significantly, i.e. the differences of body height compared to normal decreased by 0.3 SDS. The length of hand and feet, however, increased markedly more, i.e. the difference towards normal decreased by 0.65 (hand) and 0.73 (foot). The same trend proceeded throughout the second year . Resumee: More attention should be paid to changes of body proportions particularly of hands and feet during treatment with high doses of hGH.
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