Abstract
AbstractChemical fusion of a naturally occurring pharmacophore (pterocarpan) with a fluorophore (acridone) by thermally induced cascade sigmatropic rearrangement leads to the formation of a structurally different class of DNA binding ligands. Competitive binding assay in the presence of a classical minor groove binder shows the possibility of DNA minor groove binding by the ligand 4a. High cell viability of the prepared molecular probes was of utility for nuclear staining as well as cell cycle analysis through fluorescence‐activated cell sorting (FACS).
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