Acridinedione-based fluorescence ‘turn-off’ sensor for real-time detection of carcinogenic Cr (VI) ions

Abstract

This research introduces AR-1, a newly developed chemosensor tailored for Cr (VI) ion detection in semi-aqueous solutions. AR-1 demonstrates notable alterations in coloration and reduced fluorescence output upon interaction with Cr (VI) ions, showing remarkable selectivity even amidst other interfering metal ions. Fluorescence spectral titrations were employed to ascertain the binding constant and detection thresholds of the AR-1-Cr (VI) complex, with LOD and LOQ established at 0.639 µM and 0.021 μM, respectively. Further characterization via 1H NMR titrations, DFT calculations, Job’s plot, and HRMS analysis provided insights into the detection mechanism. The probe proved dependable within a pH range of 3.0 to 11.0, displaying resilience against interference from common metal ions. Overall, AR-1 presents a direct and efficient means for Cr (VI) ion detection in environmental samples, offering a promising alternative to traditional detection methods.