Abstract
Desmosomes are structurally and functionally complex intercellular adhesive junctions that provide mechanical integrity to tissues by linking the intermediate filaments of neighboring cells. The basis by which desmosomes are able to resist mechanical stress, while also participating in dynamic tissue remodeling during wound healing and morphogenesis remains poorly understood. Desmosomal cadherins are Ca2+-dependent transmembrane proteins that form the adhesive interface by binding to cadherins from neighboring cells.
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