Abstract
Twenty eight rats were given 10 acquisition sessions under a variable interval 30 sec schedule of water reinforcement for lever-press responding. This training was followed by one extinction session in which no responses were reinforced. The rats were divided into 4 groups and were administered either 0, 0.5, 2.0 or 8.0 mg Δ 9-THC per kg of body weight throughout both variable interval schedule acquisition and extinction. The presence of Δ 9-THC during acquisition suppressed variable interval response rates and decreased the number of reinforcements obtained in a dose-related manner. Likewise, a dose dependent decrease in extinction responding was obtained as compared to nondrug control extinction responding.
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