Abstract
With the growing use of sulfonamide drugs the problem of to these drugs is taking on added importance. Besides the reactions which are known to occur one to two weeks following the institution of therapy there are also seen early reactions characterized by fever, chills, rash and pruritus within a few hours after the administration of these drugs and often in response to minute doses. Salvin 1 in 1937 reported a case of such to sulfanilamide. In 1939 Thompson 2 described a similar response to sulfapyridine. And in 1940 Davidson and Bullowa 3 noted fever with chilliness, erythema, pruritus and conjunctival injection some hours after the administration of sulfamethylthiazole. As far as I am aware, such reaction has not previously been reported with sulfadiazine, presumably because this drug is the most recent addition to the group. These reactions have been termed hypersensitivity or acquired sensitivity by most authors.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
