Abstract
Acquired reactive perforating collagenosis is a rare skin disorder characterized by the presence of umbilicated pruritic papules and nodules. Transepidermal elimination of altered and perforating bundles of basophilic collagen from the epidermis is a characteristic histologic feature of acquired reactive perforating collagenosis. Along with its well-known association with systemic diseases such as diabetes mellitus, chronic renal failure, and dermatomyositis, there are reports of acquired reactive perforating collagenosis being associated with malignancies. Herein, we present a case of acquired reactive perforating collagenosis associated with chronic lymphocytic leukemia, prostate adenocarcinoma, and Graves's disease. Clinicians are required to be more vigilant in evaluating patients with acquired reactive perforating collagenosis due to its unique association with malignancies and other systemic diseases.
Highlights
ଝ How to cite this article: Huseynova L, Akdogan N, Gököz Ö, Evans SE
ARPC is more common than the hereditary form; unlike the hereditary form, ARPC is characterized by a typical adult-onset
Transepidermal elimination of altered dermal collagen is thought to be crucial for the pathogenesis of ARPC
Summary
Acquired reactive perforating collagenosis in association with prostate adenocarcinoma, chronic lymphocytic leukemia, and Graves’ disease. Collagen from the epidermis.[1] the etiology and pathogenesis of ARPC are not fully understood, the disease is commonly associated with systemic diseases such as diabetes mellitus (DM), chronic renal insufficiency, dermatomyositis, hyperuricemia, and malignancies.
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