Abstract
<b>1594</b> <h3><b>Objectives</b></h3> In the treatment of patients with solid primary and metastases liver tumors two devices based on microspheres are on the market.SIRTex offers SIR-Spheres based on resin and TheraSpheres based on activated glass microspheres. The intention of our work was the synthesis of novel Ga-68 and Y-90-labelled spheres based on biodegradable microspheres. <h3><b>Methods</b></h3> A mixture of poly(ϵ-caprolactone) and polyvinylalcohole /water was heated up to 80°C for 20 min and cooled down at room temperature.The generated spheres hardened within 2 h and the required size range was achieved by fractionated centrifugation. Surface modification was carried out by amination using EDA. The second free amine group allowed the coupling with DOTA chelator and subsequently the labelling with Ga-68 and Y-90. Animal studies were carried out on Sprague Dawley rats.The bio-distribution of the Ga-68 radiolabeled microspheres were estimated using the micro PET scanner. <h3><b>Results</b></h3> We obtained microspheres between 30 ~ 50 µm.The successful implementation of EDA was confirmed by coupling to FITC. The coupling of DOTA enabled the Ga-68 labelling with an efficiency of 55±5%. The Y-90 labelling resulted in yields of 45±5%. After purification the radiochemical purity was always higher than 97%. As a dimension of the stability the radioactivity recovery in the lungs was used. As expected the microspheres were completely retained in the lung and the time-activity curve which acted as a proof for the in-vivo stability showed no decrease of activity or migration of microspheres. <h3><b>Conclusions</b></h3> We could show successfully the use of solid surface modificated spheres based on biological degradable polymers for the estimation of the biodistribution, exclusion of a lung-shunt and as possible therapy surrogates for Y-90 labelled SIR-Spheres. The potentiality of this spheres needs to be further explored and polymers which allow higher reaction temperatures and labelling yields are under investigation
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