Acquired haemolytic anaemia; clinical and serological observations of two cases.

Abstract

From National Health Survey 2010 (ENS) non-diabetic subjects between 20 and 64 years old were selected. We constructed a clinical prediction rule (CPR) based on the variables of the STOP-Bang Questionnaire. According to the score obtained, they were classified as LOW (<3), MEDIUM (3-4) and HIGH (≥5) for AOS, respectively. The results of glycosylated haemoglobin (HbA1c), fasting glycemia and hemoglucotest (HGT) were compared between the OSA risk groups by means of an ANOVA test. The sample analysed was 3,159 subjects, with an average age of 41.1 ± 12.3 years, of which 1903 (60.2%) were women. They classified as risk LOW 1.972 (67.9%), MEDIUM 783 (26.9%), and HIGH 151 (5.2%). The HbA1c results in men: LOW risk = 5.61 (± 0.41), MEDIUM = 5.82 (± 0.45), HIGH = 5.86 (± 0.44) (p <0.001). The results of fasting blood glucose in men: risk LOW = 88.9 (± 8.24), MEDIUM = 92.6 (± 10.12) and HIGH = 95.43 (± 9.92) (p <0.001). The results of HGT in men: risk LOW = 95.15 (± 14.16), MEDIUM = 98.85 (± 14.36), HIGH = 101.23 (± 12.12) (p <0.001). HbA1c results in women: risk LOW = 5.74 (± 0.47), MEDIUM = 6.11 (± 0.67) and HIGH = 6.08 (± 0.43) (p <0.001). The results of fasting glycemia in women: LOW risk = 86.66 (± 8.58), MEDIUM = 91.49 (± 10.74), HIGH = 97.68 (± 11.53) (p <0.001). The results for HGT in women: LOW risk = 92.60 (± 12.03), MEDIUM = 98.37 (± 14.82), HIGH = 103.75 (± 17.22) (p <0.001). The results of Hb1Ac for LOW risk: Men = 5.61 (± 0.41), Women = 5.74 (± 0.47) (p <0.05); for MEDIUM risk: Men = 5.82 (± 0.45), Women = 6.11 (± 0.67) (p <0.05). We find association between the risk of OSA and impaired glucose metabolism in non-diabetic subjects.