Abstract
The mechanical state of a drug tablet is an important factor in its physical form and therapeutic function. In recent years, a strong need for new technologies for faster and more reliable quality assurance has often been voiced by both regulators and manufacturers. In the current study, a novel air-coupled acoustic technique is demonstrated as a noncontact/nondestructive method for mechanical characterization and coating thickness determination of tablets. For verification purposes, a contact ultrasonic scheme is employed. Applications of the technique in solid dosage form characterization and process monitoring applications and its role as a potential PAT tool are discussed.
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