Abstract
Methods In this controlled multicentre phase IV study, HDM adult allergic patients were randomized to receive subcutaneous immunotherapy with a 10 IR/ml depot extract plus symptomatic treatment (group A) or only symptomatic treatment (group B) (2:1). Acoustic rhinometry after nasal provocation test (NPT) was selected to objectively assess the efficacy of this treatment by measuring the nasal volume (NV) and minimum cross-sectional area (MCA). A visual analogic scale (VAS) has been used to subjectively assess the efficacy (0-10 scale, lower is better)NPT consists in 5 determinations at intervals of 15 minutes (basal, diluent, 0.01 IR, 0.1 IR, 1 IR) and one last determination 30 minutes after the last administration. The extract used for the NPT was 100 IR/ml of D. pteronyssinus.
Highlights
ALUMITES study was designed to assess the efficacy of house dust mites (HDM: D. pteronyssinus + D. farinae) subcutaneous immunotherapy for the treatment of allergic rhinitis patients along one year
A visual analogic scale (VAS) has been used to subjectively assess the efficacy (0-10 scale, lower is better)nasal provocation test (NPT) consists in 5 determinations at intervals of 15 minutes and one last determination 30 minutes after the last administration
The extract used for the NPT was 100 IR/ml of D. pteronyssinus
Summary
Acoustic rhinometry after nasal provocation test, 6 months interim analysis of alumites study, a randomized, controlled, multicentre phase IV study with house dust mites subcutaneous immunotherapy. Jaime Sanchez1*, Carmen Vidal, Dolores Hernandez, Antonio Valero, Jose Vicente Castello, Antonio Pelaez, Mario Alberto Garcia. From 9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013) Leuven, Belgium. From 9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013) Leuven, Belgium. 21-23 March 2013
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