Acoustic Radiation Force Impulse (ARFI) imaging for the distinction between benign and malignant thyroid nodules.

Abstract

The aim of the present study was to evaluate thyroid nodules using virtual touch quantification (VTQ) of force impulse acoustic radiation (ARFI) imaging and to investigate a cutoff value for the differentiation of malignant thyroid nodules. Ninety-five patients with quantitatively-assessed (VTQ) thyroid nodules were evaluated with ARFI imaging in this prospective study. ARFI imaging with VTQ was performed only on the nodules which were expected to undergo fine-needle aspiration biopsy (FNAB). All of the thyroid lesions were examined histopathologically. The mean shear wave velocity (SWV) value of the malignant nodules (3.18±0.39m/s) was higher than that of the benign nodules (2.11±0.53m/s). There was a statistically significant difference between the mean SWV values of benign and malignant nodules (p<0.001). A SWV cutoff value of greater than 2.66m/s yielded sensitivity and specificity values of 100 and 82.3%, respectively, for diagnosis of malignant nodules. VTQ of ARFI imaging has high sensitivity and specificity for discriminating between benign and malignant thyroid nodules and may positively contribute to clinical evaluation of these nodules.