Abstract
Abstract Diameters of particles used as ultrasound contrast agents are limited by capillary diameters to about 8 μm, much smaller than the acoustic wavelength used in diagnostic ultrasound. Strong acoustic backscatter from such small particles is achieved by using gas-containing particles encapsulated in a shell. The shell makes the acoustic properties of these particles differ from that of gas-bubbles. It is shown how acoustic behaviour of such particles can be explained from their size and compressibility. The particle bulk modulus K was described with the Kelvin-Voigt model for visco-elastic solids, K = K0 + iωμ, where the parameters K0 and μ were found from acoustic attenuation spectra. Application of this model to an experimental contrast agent from Nycomed Imaging gave as a result K0 = 2.2 MPa, μ = 0.080 Pa · s.
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