Abstract
Force-spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Acoustic Force Spectroscopy (AFS) is a new acoustic manipulation method, which consists of a resonator integrated into a micro-fabricated fluidic chip. An acoustical pressure gradient is created homogeneously throughout the sample enabling to exert forces on DNA-tethered microspheres. By changing the amplitude of the driving voltage the pressure gradient can be altered, allowing sensitive control of the force applied to the DNA molecules. This approach allows exerting acoustic forces from sub-pN to hundreds of pN applied to thousands of biomolecules in parallel, with sub-millisecond response time and inherent stability. Here we present the next step in validating this new technology, a stand-alone commercial grade prototype, that makes this method available to the wider scientific community.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
