Abstract
Transcranial MR-guided Focused Ultrasound (TcMRgFUS) treatments are now clinically performed on adult patients for brain tumor or essential tremor therapies. However, no application has been proposed for children despite their thinner skull being less of an acoustic barrier and the presence of a fontanelle on neonates, which could constitute a natural acoustic window for the transmission of ultrasound waves. As there is minimal literature data on the attenuation and speed-of-sound of the skull in neonatal patients, the aim of this study was to perform the acoustic characterization of a neonate skull.
Highlights
Background/introduction Transcranial MR-guided Focused Ultrasound (TcMRgFUS) treatments are clinically performed on adult patients for brain tumor or essential tremor therapies
When the acoustic axis of the transducer was normal to the fontanelle, the average Insertion losses (IL) and TOF delay due to the fontanelle were respectively 0.9 ± 0.8 dB and -0.09 ± 0.02 μs at 1 MHz
At 1.2 MHz, the IL decreased at 0.5 ± 0.5 dB and the TOF delay remained the same
Summary
Background/introduction Transcranial MR-guided Focused Ultrasound (TcMRgFUS) treatments are clinically performed on adult patients for brain tumor or essential tremor therapies. No application has been proposed for children despite their thinner skull being less of an acoustic barrier and the presence of a fontanelle on neonates, which could constitute a natural acoustic window for the transmission of ultrasound waves. As there is minimal literature data on the attenuation and speed-of-sound of the skull in neonatal patients, the aim of this study was to perform the acoustic characterization of a neonate skull
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