Abstract
High intensity soundwaves, such as shockwaves and HIFU, are widely used in biomedical applications, for example, extracorporeal shockwaves lithotripsy (ESWL) and HIFU prostate cancer treatment. The high pressure in the tissue and nearby fluid often causes formation of cavitation bubbles. Our previous simulation results via BEM approach show complex bubble ultrasound interactions: in certain cases a jet is formed directed away from the nearby tissue while in others, towards it [Fong et al., Ultrasound Biol. Med., 32(6), 925–942, 2006]. In the present work, pulsed ultrasound microbubble interaction is studied using the same code to provide further understanding to the jetting behavior of the bubbles near (different) biomaterial surface which is critical to the success of tissue ablation and the minimization of auxiliary damages. Separately, we have also simulated shockwave bubble interaction using the BEM code with excellent concurrence to other compressible numerical schemes such as arbitrary Lagrangian-Eulerian and free Lagrange methods [Klaseboer et al., Comput. Methods Appl. Mech. Eng. 195, 4287–4302 (2006)] and experiments. It is suggested that the (primary) dynamic response of the bubble to soundwaves is mainly inertia controlled since compressibility of the fluid is not modeled.
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