Abstract
Regeneration Some animals, including some types of worms, can undergo whole-body regeneration and replace virtually any missing cell type. Gehrke et al. sequenced and assembled the genome of Hofstenia miamia , a regenerative acoel worm species (see the Perspective by Alonge and Schatz). They identified a variable motif corresponding to regulation of the early growth response ( egr ) gene that was involved in regeneration. RNA interference experiments and validation in a second species showed that the protein Egr is a pioneer factor that stimulates regeneration. Science , this issue p. [eaau6173][1]; see also p. [1152][2] [1]: /lookup/doi/10.1126/science.aau6173 [2]: /lookup/doi/10.1126/science.aaw6258
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