Abstract
Objective
 We aimed to investigate the diagnostic accuracy of
 copeptin to detect transient ischemic attack (TIA) by
 comparing the plasma copeptin levels of patients diagnosed
 with TIA who were admitted to the Emergency
 Department (ED) with those of healthy controls.
 Materials and Methods
 We conducted a prospective case-control study
 among patients admitted to the ED with a neurological
 symptom. The patients diagnosed with TIA by the
 neurologist were included. The results of electrocardiography,
 magnetic resonance imaging, and carotid
 doppler ultrasonography investigations of 38 patients;
 the ED outcomes (hospitalization, discharge), the risk
 group distribution (according to ABCD2 scores), and
 the variables regarding one-year re-event incidence
 were compared. Additionally, the serum copeptin levels
 of the patients were compared to those of healthy
 controls.
 Results
 The mean copeptin level was 435.80 ± 316.45 pg/ml
 in the patient group, whereas it was 770.20 ± 912.53
 pg/ml in the control group. The mean copeptin level of
 patients with TIA was significantly lower (p = 0.018). In
 the diagnosis of TIA, copeptin had 60.53% sensitivity
 and 68.42% specificity at a cut-off value of 386.28 pg/
 ml, in all the participants. In addition, in participants
 above 60 years old, copeptin had 75.86% sensitivity
 and 72.41% specificity at a cut-off value of 460.37 pg/
 ml.
 Conclusion
 To the best of our knowledge, this is the first study
 demonstrating the high efficacy of a serum biomarker
 in the diagnosis of TIA. Emergency physicians should
 search for alternative diagnoses in patients with a low
 degree of clinical suspicion and a lower copeptin value.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
