Abstract
A study was made of fifty patients having acinic cell carcinoma, including forty-seven tumors of the parotid gland and three sub-maxillary tumors, treated at the Mayo Clinic from 1918 through 1961. Follow-up study in forty-six cases ranged from one to forty-one years after initial treatment. Evidence presented supports the concepts that these tumors originate in acini of the salivary gland and that they should be considered as malignant tumors. The results of treatment indicate that a more aggressive surgical approach at the time of initial therapy offers the best opportunity for cure. More than 100 cases of acinic cell carcinoma of the parotid gland have been reported in the literature.
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