Abstract
IntroductionWe report an observational study on the etiology and recurrence of acinic cell carcinoma of the parotid gland that seemed to be related to pregnancy. The medical literature has never reported such an association; therefore, our case report is probably the first to mention this observation.Case presentationThis report is of a 25-year-old Arabic female patient from the United Arab Emirates, who, during her first pregnancy, developed acinic cell carcinoma of the right parotid gland that was managed with surgical excision in the form of superficial parotidectomy. During her second pregnancy, which occurred four years later, she had a recurrence of the same malignant neoplasm associated with ipsilateral malignant cervical lymphadenopathy. The patient was managed with total parotidectomy and neck dissection, as well as postoperative adjuvant radiotherapy. Our observation on this particular case of acinic cell carcinoma is that the initial onset of her neoplasm was during her first pregnancy, and the recurrence of the same malignant disease was during a subsequent pregnancy. This chronologic association raised our suspicion that there might be a possible etiologic effect of pregnancy or its associated hormonal or physiologic changes or both on the pathogenesis or etiology of acinic cell carcinoma.ConclusionSome association might exist between pregnancy and the pathogenesis or etiology of acinic cell carcinoma.
Highlights
We report an observational study on the etiology and recurrence of acinic cell carcinoma of the parotid gland that seemed to be related to pregnancy
Some association might exist between pregnancy and the pathogenesis or etiology of acinic cell carcinoma
The medical literature that we thoroughly reviewed had no mention of effect of pregnancy on the development or the recurrence of this malignant neoplasm we observed in this case
Summary
Acinic cell carcinoma (ACC) is a rare malignant epithelial salivary neoplasm of a ductal cell origin. Case presentation A 25-year-old Arabic female patient from the United Arab Emirates developed a right parotid mass lesion that was otherwise completely asymptomatic and of a stable size She had no history of head and neck radiation treatment or a personal or family history of salivary neoplasms, but she was in the second trimester of her first pregnancy. During the third trimester of her pregnancy, she developed a new mass lesion at the same site as her previous parotidectomy, which proved to be a recurrent acinic cell carcinoma She had a right submandibular malignant lymphadenopathy. All investigations were essentially unremarkable, and no evidence of distant metastases or contraindications for surgical treatment were present Her CT scan confirmed the presence of the recurrent mass lesion of the right parotid gland (Figure 1). Her disease has been well controlled until the time of this report, and she has had no recurrence of her acinic cell carcinoma
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
