Abstract
Acinar cell carcinoma is a rare malignant epithelial neoplasm, composed of cells which morphologically resemble acinar cells and produce pancreatic enzymes. It is totally unrelated to acinar cell nodules or the benign entity acinar cell cystadenoma, both of which are discussed elsewhere in the book. Acinar cell carcinoma may show a wide range of morphological appearances, ranging from well-differentiated acinar structures to solid sheets of poorly differentiated cells, which can cause diagnostic difficulty. These macroscopic and histological features of acinar cell carcinoma and its variants are discussed. There is also detailed discussion of the differential diagnosis and the morphological features and immunohistochemical profiles (tabulated in Chap. 20) which can be used to distinguish these different diagnostic entities.
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