Abstract
It has been shown that acidosis can decrease calcium entry and inhibit neurotransmitter release from nerve cells1; these effects may, therefore, interfere with the coupling action of calcium in cellular secretion and muscular contraction processes. Oral administration of ammonium chloride, an acidifying agent, induces gastric ulceration in rats2. Thus, acidosis appears to have a marked influence on gastric function. Cold-restraint stress is known to produce gastric ulceration3, however, its effects on the blood acid-base balance have not been studied. Thus, it is conceivable that the occurrence of acidosis may play a role in stress-induced gastric ulceration. This chapter reports the results of a study to determine whether or not the changes in acid-base balance by cold-restraint stress are causally related to gastric ulcer formation in rats. The effects of some of antiulcer drugs on these parameters are also examined.
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