Acidosis activates complement system in vitro.

Freek J Zijlstra

doi:10.1080/09629359990649

Abstract

We investigated the in vitro effect of different forms of acidosis (pH 7.0) on the formation of anaphylatoxins C3a and C5a. Metabolic acidosis due to addition of hydrochloric acid (10 micromol/ml blood) or lactic acid (5.5 micromol/ml) to heparin blood (N=12) caused significant activation of C3a and C5a compared to control (both p=0.002). Respiratory acidosis activated C3a (p=0.007) and C5a (p=0.003) compared to normocapnic controls. Making blood samples with lactic acidosis hypocapnic resulted in a median pH of 7.37. In this respiratory compensated metabolic acidosis, C3a and C5a were not increased. These experiments show that acidosis itself and not lactate trigger for activation of complement components C3 and C5.

Highlights

Looking back to Volume 7 which had been published in 1998 both the Editors and the Publisher were very satisfied concerning layout and content of the journal
That means that more full papers and Reviews were published in comparison with the high number of Short Communications during the first 6 Volumes
Copy flow of high standing Research papers is a matter of concern, the processing speed is still improving, resulting in an average acceptance–publication time of less than 3 months! it could be mentioned that over 75% of the articles are from authors in Europe, geographic analysis of the subscribers learned that over 40% of the journal was distributed in the USA

Summary

Introduction

Looking back to Volume 7 which had been published in 1998 both the Editors and the Publisher were very satisfied concerning layout and content of the journal. It is a pleasure to welcome readers of the journal at the start of the last year of this century looking forward to the millenium. 60 papers were accepted and published in Volume 7, covering the 432 pages available for 6 issues.

Results

Conclusion