Abstract
The acidity constants of some tetrazole compounds were determined pH-metrically at 25 °C and at the constant ionic strength I = 0.1 mol dm-3 (KNO3) in pure water as well as in various aqueous mixtures having variable mole fractions (0.05−0.3) of organic solvents. The organic solvents used are methanol, ethanol, N,N-dimethylformamide, dimethyl sulfoxide, and acetone. Generally, the pKa values increase with an increase in the content of the organic solvent. It was concluded that the major effects responsible for this behavior are, in addition to the electrostatic effect, the stabilization of the conjugate base by hydrogen-bonding interactions with solvent molecules and solvent basicity. Effect of molecular structure of tetrazoles on the pKa values is discussed. Moreover, the thermodynamic functions (ΔH, ΔG°, and ΔS°) associated with the ionization process of investigated compounds in a pure aqueous medium are derived and their values are discussed.
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